Cornea

Corneal Graft Rejection

Also known as: corneal graft rejection, corneal transplant rejection, graft rejection, keratoplasty rejection, penetrating keratoplasty rejection, endothelial rejection, Khodadoust line, RSVP graft rejection

Clinical decision support only

OptoGuide™ supports professional judgement and does not diagnose or replace clinician responsibility.

Overview

Immune rejection of a corneal transplant is sight-threatening and time-sensitive. The key patient-facing warning pattern is RSVP: Redness, Sensitivity/photophobia, Vision decrease, and Pain. Optometry should recognise the pattern, look for infection or loose suture mimics, document graft findings, and arrange urgent same-day cornea specialist/ophthalmology review. Steroid escalation is specialist-managed and should not be presented as an optometrist prescribing CTA.

What OptoGuide™ covers for corneal graft rejection

Recognition patterns — symptoms, signs, and differentiators
Don't-miss risks and escalation triggers
Management tiers with linked Australian therapeutics
Referral urgency, specialty, and letter drafting

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